Predictive models for HIV related Lymphomas – Prof Nyabadza
Prof Farai Nyabadza
Title of the project
Predictive models for HIV related Lymphomas
This project is part of a multidisciplinary study on HIV related Lymphomas (HRLs) in the Western Cape province of South Africa, under the Tygerberg Lymphoma Study Group (TLSG) of the University of Stellenbosch medical school. The TLSG is a cross-disciplinary and highly-collaborative research entity based at Tygerberg Hospital. The team consists of scientists who aim to unravel the complexities of HIV related cancer progression through hematopathological techniques and mathematical modeling. The mastery of its investigators span the disciplines of Medical Sciences and Mathematics. Our collaborative mandate is to produce mathematical models that can be fitted to data based on known demographic features of the population and applying this to prospective scenarios. At the heart of this project is the application mathematics to cancer research. This is a field that is increasingly being seen as an essential component in the future of cancer research. The focus will be on two fronts (i) the use of data from the TLSG to design models that can be used as national HRLs trends prediction tools and (ii) modelling the interaction of the immune system and cancer cells. With regards to the former, a cost-benefit and cost-effectiveness analysis will be carried out based on the model outputs. Projections allow for planning and influencing of policy. With regards to the later, mathematical modelling is intertwined with experimental work, as it elucidates significant relationships that has contributed to the current cancer treatments. This innovative proposed project will therefore, through the interaction with experimental and social sciences, be well-aligned with the scientific objectives of CANSA.