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Research Projects

Impact of Cisplatin-induced Hearing Loss on Health-related Quality of Life: A Prospective Cohort Study

Impact of Cisplatin-induced Hearing Loss on Health-related Quality of Life: A Prospective Cohort Study

A/Prof Lebogang Ramma

A/Prof Lebogang Ramma

Title of the project

Impact of cisplatin-induced hearing loss on health-related quality of life: A prospective cohort study.

Project Description

Cisplatin is a highly effective and it is a widely used chemotherapeutic drug for treatment of solid tumours. However, one of its major side effects is permanent hearing loss which may occur in up to 75% or more of patients who are treated with it. In most developing countries such as South Africa majority of patients who develop hearing loss due to cisplatin chemotherapy do not get the necessary assistance for their hearing difficulties and this tends to have a negative impact on their well-being. It is widely accepted that given advances in medical technology which have significant improvements in survival rates for cancer patients, traditional methods of evaluating health outcomes in these patients (e.g. using mortality rates) are not adequate. Evaluation of health outcomes should therefore include assessment of well-being of cancer survivors. The purpose of this study is to investigate the impact of hearing loss that result from cisplatin chemotherapy for treatment of cancer on patients’ health-related quality of life (well-being).


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