Prof Francois van der Westhuizen – Early multimodal detection of cancers originating from synthetic hormonal therapy in a p53 knockout murine model
Prof Francois van der Westhuizen
- Professor of Biochemistry, Centre for Human Metabonomics, Potchefstroom Campus, North-West University
Title of the project
Early multimodal detection of cancers originating from synthetic hormonal therapy in a p53 knockout murine model.
The central research aim of this study is to investigate novel biochemical and nanoparticle imaging approaches for early cancer detection, which could possibly be applied to early detection and prevention strategies. The study will use a p53 knockout murine model, deficient in the tumor suppressor protein p53, which develops various types of neoplasia spontaneously from 3 – 6 months of age, which is well into the mature phase of murine life-cycle. Considering our interest and expertise in metabolism and bioenergetics, we propose two main objectives for this study:
Firstly, evaluate the susceptibility of the murine model to undergo carcinogenesis in the absence and presence of oral (hormonal) contraceptives with the use of biochemical profiles, generated for the mouse model.
The second objective of the study is to develop a nanoparticle-based imaging technique, which could detect as well as track cancer development in this mouse model.