Research Projects

Prof Christopher Mathew – Identifying genetic markers of susceptibility to African Oesophageal Cancer

Prof Christopher Mathew – Identifying genetic markers of susceptibility to African Oesophageal Cancer

Prof Christopher Mathew

Prof Christopher Mathew

Prof Christopher Mathew

Title of the project

Identifying genetic markers of susceptibility to African Oesophageal Cancer.

Project Description

Oesophageal squamous cell carcinoma (OSCC) is common in Black populations of sub-Saharan Africa, with high incidence regions in East and South Africa. Clinical presentation in Africa is late, and treatment is mainly palliative with a very poor prognosis. Various environmental risk factors have been identified, but the possible contribution of genetics to disease risk is an important question which is unresolved.

The main purpose of this project is to test the hypothesis that genetic variation in the South African Black population contributes significantly to the risk of this type of cancer. This will be done by testing genetic risk factors for OSCC which have been identified in other populations for association with OSCC in the South African Black population, and by carrying out fine-scale genetic mapping in positive loci to identify causal genes and variants.

We also seek to confirm preliminary evidence of several novel associations of OSCC which we detected in Black cases and controls from the Cape Province.

« BACK


Do you have a question?